5-Amino-1MQ

Scientific Benefits

• Fat Cell Shrinkage — NNMT inhibition reduces lipid accumulation in adipocytes, causing measurable fat cell size reduction without affecting lean mass.
• Metabolic Rate Elevation — Raises basal metabolic rate by increasing intracellular NAD+ levels and activating AMPK and sirtuin pathways.
• NAD+ Enhancement — Preserving methyl donors from NNMT shunts them toward NAD+ synthesis, amplifying mitochondrial energy production and DNA repair.
• Visceral Fat Targeting — Shows preferential reduction of metabolically harmful visceral fat in preclinical models.
• Lean Mass Preservation — Fat loss occurs without loss of muscle mass; complementary anabolic signaling preserved.
• Insulin Sensitivity — Reduction in adipose tissue and increased NAD+ levels improve insulin receptor sensitivity and glucose tolerance.
• Synergy with NAD+ Precursors — Combining with NMN or NR (NAD+ precursors) produces additive NAD+ elevation effects.