MOTS-c
10mg/vial
Mitochondrial-Derived Peptide
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA gene. This unique peptide regulates metabolic homeostasis by activating AMPK pathways, enhancing glucose uptake, and promoting mitochondrial biogenesis for optimal cellular energy production.
Research Metrics
HPLC verified purity
Enhanced metabolic sensing
Peptide length
Mitochondrial encoded
Mechanism of Action
Activates AMPK via AICAR-independent pathway. Translocates from mitochondria to nucleus during metabolic stress, acting as a retrograde mitochondrial signal that coordinates nuclear gene expression for metabolic adaptation.
Scientific Benefits
- Metabolic Regulation — Activates AMPK pathway, improving glucose uptake, fatty acid oxidation, and insulin sensitivity.
- Exercise Performance — Increases endurance and physical performance by enhancing mitochondrial efficiency and energy utilization.
- Anti-aging — Circulating MOTS-c levels decline with age; supplementation reverses age-related metabolic decline in animal models.
- Obesity Prevention — Inhibits de novo lipogenesis and promotes fat loss, particularly visceral adipose tissue.
- Glucose Homeostasis — Improves insulin resistance and glucose tolerance, relevant for type 2 diabetes prevention.
- Stress Response — Translocates to the nucleus under stress to regulate gene expression and adaptive stress response.
- Longevity Signaling — Associated with increased lifespan in animal studies; mirrors benefits of caloric restriction.
Disclaimer & Usage Notice
GENERAL USAGE NOTICE. The products offered on this website are sold strictly for your own personal purposes. By purchasing, you acknowledge that you are assuming all risks associated with the handling and application of these products.
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